Drug interactions
Ciprofloxacin + Haloperidol
Severity: Moderate
Ciprofloxacin and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol prolongs the QT interval and carries a known risk of torsades de pointes, and ciprofloxacin adds a small additional QT effect. The risk is greatest with high-dose or intravenous haloperidol, electrolyte disturbances, or underlying heart disease.
What this interaction means in plain words
Ciprofloxacin and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Haloperidol belongs to Central Nervous System.
Why it happens
Additive blockade of cardiac potassium channels (hERG), leading to delayed repolarization and QT prolongation.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Monitor QTc, and choose a different antibiotic if QTc becomes markedly prolonged or the patient has several risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Haloperidol?
MediHelp rates the interaction as moderate. Ciprofloxacin and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol prolongs the QT interval and carries a known risk of torsades de pointes, and ciprofloxacin adds a small additional QT effect. The risk is greatest with high-dose or intravenous haloperidol, electrolyte disturbances, or underlying heart disease.
How serious is the interaction between Ciprofloxacin and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Monitor QTc, and choose a different antibiotic if QTc becomes markedly prolonged or the patient has several risk factors.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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