Drug interactions
Ciprofloxacin + Iloperidone
Severity: Moderate
Ciprofloxacin and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QTc interval and ciprofloxacin may add a small further effect. The risk of arrhythmia increases in patients with bradycardia, electrolyte disorders or structural heart disease.
What this interaction means in plain words
Ciprofloxacin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Iloperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation through effects on cardiac repolarisation.
What to do
Check baseline ECG and electrolytes and monitor the QTc during the antibiotic course. Choose an alternative antibiotic if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Ciprofloxacin with Iloperidone?
MediHelp rates the interaction as moderate. Ciprofloxacin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone prolongs the QTc interval and ciprofloxacin may add a small further effect. The risk of arrhythmia increases in patients with bradycardia, electrolyte disorders or structural heart disease.
How serious is the interaction between Ciprofloxacin and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor the QTc during the antibiotic course. Choose an alternative antibiotic if other QT risk factors are present.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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