Drug interactions
Ciprofloxacin + Itraconazole
Severity: Moderate
Ciprofloxacin and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and itraconazole also inhibits CYP3A4, which can raise levels of other QT-prolonging drugs. The combined effect increases the chance of torsades de pointes, especially with electrolyte disturbances or heart disease.
What this interaction means in plain words
Ciprofloxacin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Itraconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Check baseline ECG and correct potassium and magnesium. Monitor QTc, and avoid the combination in patients with congenital long QT or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Itraconazole?
MediHelp rates the interaction as moderate. Ciprofloxacin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and itraconazole also inhibits CYP3A4, which can raise levels of other QT-prolonging drugs. The combined effect increases the chance of torsades de pointes, especially with electrolyte disturbances or heart disease.
How serious is the interaction between Ciprofloxacin and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium. Monitor QTc, and avoid the combination in patients with congenital long QT or other QT-prolonging drugs.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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