Drug interactions
Ciprofloxacin + Ivacaftor
Severity: Minor
Ciprofloxacin and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor can inhibit P-glycoprotein and may modestly raise ciprofloxacin levels, while ciprofloxacin is a weak CYP3A4 inhibitor that could slightly raise ivacaftor exposure. Both effects are expected to be small.
What this interaction means in plain words
Ciprofloxacin and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Ivacaftor belongs to Miscellaneous.
Why it happens
Ivacaftor inhibits P-gp efflux of ciprofloxacin, and ciprofloxacin weakly inhibits CYP3A4 metabolism of ivacaftor.
What to do
No dose adjustment is typically needed. Monitor for adverse effects of either drug, such as transaminase elevation with ivacaftor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ciprofloxacin and Ivacaftor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ciprofloxacin with Ivacaftor?
MediHelp rates the interaction as minor. Ciprofloxacin and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor can inhibit P-glycoprotein and may modestly raise ciprofloxacin levels, while ciprofloxacin is a weak CYP3A4 inhibitor that could slightly raise ivacaftor exposure. Both effects are expected to be small.
How serious is the interaction between Ciprofloxacin and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is typically needed. Monitor for adverse effects of either drug, such as transaminase elevation with ivacaftor.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
