Drug interactions
Ciprofloxacin + Lomitapide
Severity: Major
Ciprofloxacin and Lomitapide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin is a weak to moderate CYP3A4 inhibitor and can raise lomitapide exposure, increasing the risk of hepatotoxicity and gastrointestinal effects. Lomitapide labelling requires dose limits with weak CYP3A4 inhibitors.
What this interaction means in plain words
Ciprofloxacin and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Lomitapide belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lomitapide by ciprofloxacin.
What to do
Limit the lomitapide dose as directed in the labelling while ciprofloxacin is given, and monitor liver enzymes and GI tolerance. Consider an alternative antibiotic for prolonged courses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Lomitapide?
MediHelp rates the interaction as major. Ciprofloxacin and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ciprofloxacin is a weak to moderate CYP3A4 inhibitor and can raise lomitapide exposure, increasing the risk of hepatotoxicity and gastrointestinal effects. Lomitapide labelling requires dose limits with weak CYP3A4 inhibitors.
How serious is the interaction between Ciprofloxacin and Lomitapide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lomitapide dose as directed in the labelling while ciprofloxacin is given, and monitor liver enzymes and GI tolerance. Consider an alternative antibiotic for prolonged courses.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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