Drug interactions
Ciprofloxacin + Lonafarnib
Severity: Major
Ciprofloxacin and Lonafarnib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and ciprofloxacin is a weak to moderate CYP3A inhibitor, so lonafarnib exposure may rise. Higher lonafarnib levels could increase GI toxicity, and ciprofloxacin adds its own QT effect.
What this interaction means in plain words
Ciprofloxacin and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Lonafarnib belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated lonafarnib metabolism by ciprofloxacin, plus possible additive QT effects.
What to do
Use an alternative antibiotic if possible. If needed, keep lonafarnib at the starting dose and monitor for arrhythmia symptoms, ECG changes and toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Lonafarnib?
MediHelp rates the interaction as major. Ciprofloxacin and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a sensitive CYP3A substrate, and ciprofloxacin is a weak to moderate CYP3A inhibitor, so lonafarnib exposure may rise. Higher lonafarnib levels could increase GI toxicity, and ciprofloxacin adds its own QT effect.
How serious is the interaction between Ciprofloxacin and Lonafarnib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic if possible. If needed, keep lonafarnib at the starting dose and monitor for arrhythmia symptoms, ECG changes and toxicity.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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