Drug interactions
Ciprofloxacin + Metoprolol
Severity: Minor
Ciprofloxacin and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin has been reported to raise metoprolol exposure in a few patients, which could cause more bradycardia or hypotension. The effect is not well characterized and is unlikely to matter in most patients.
What this interaction means in plain words
Ciprofloxacin and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Metoprolol belongs to Cardiovascular.
Why it happens
Mechanism is not established; weak inhibition of CYP2D6-mediated metoprolol metabolism has been proposed.
What to do
No routine change is needed; check heart rate and blood pressure when ciprofloxacin is started in patients on metoprolol, especially if they are elderly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Ciprofloxacin with Metoprolol?
MediHelp rates the interaction as minor. Ciprofloxacin and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ciprofloxacin has been reported to raise metoprolol exposure in a few patients, which could cause more bradycardia or hypotension. The effect is not well characterized and is unlikely to matter in most patients.
How serious is the interaction between Ciprofloxacin and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check heart rate and blood pressure when ciprofloxacin is started in patients on metoprolol, especially if they are elderly.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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