Drug interactions
Ciprofloxacin + Pomalidomide
Severity: Moderate
Ciprofloxacin and Pomalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is metabolized partly by CYP1A2, which ciprofloxacin inhibits strongly. Exposure to pomalidomide may rise, increasing myelosuppression and other adverse effects.
What this interaction means in plain words
Ciprofloxacin and Pomalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Pomalidomide belongs to Miscellaneous.
Why it happens
Ciprofloxacin inhibition of CYP1A2-mediated pomalidomide metabolism.
What to do
If a strong CYP1A2 inhibitor must be used, reduce the pomalidomide dose as per labeling and monitor blood counts. Otherwise choose a non-CYP1A2-inhibiting antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Ciprofloxacin with Pomalidomide?
MediHelp rates the interaction as moderate. Ciprofloxacin and Pomalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pomalidomide is metabolized partly by CYP1A2, which ciprofloxacin inhibits strongly. Exposure to pomalidomide may rise, increasing myelosuppression and other adverse effects.
How serious is the interaction between Ciprofloxacin and Pomalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If a strong CYP1A2 inhibitor must be used, reduce the pomalidomide dose as per labeling and monitor blood counts. Otherwise choose a non-CYP1A2-inhibiting antibiotic.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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