Drug interactions
Ciprofloxacin + Rilpivirine
Severity: Moderate
Ciprofloxacin and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine can prolong the QT interval at supratherapeutic doses, and ciprofloxacin has a modest QT effect. The combination may add to arrhythmia risk in susceptible patients.
What this interaction means in plain words
Ciprofloxacin and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Rilpivirine belongs to Anti Virals.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check baseline ECG in patients with other QT risk factors and correct electrolyte abnormalities. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Rilpivirine?
MediHelp rates the interaction as moderate. Ciprofloxacin and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine can prolong the QT interval at supratherapeutic doses, and ciprofloxacin has a modest QT effect. The combination may add to arrhythmia risk in susceptible patients.
How serious is the interaction between Ciprofloxacin and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG in patients with other QT risk factors and correct electrolyte abnormalities. Monitor for palpitations or syncope.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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