Drug interactions
Ciprofloxacin + Solifenacin
Severity: Moderate
Ciprofloxacin and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin carries a small risk of QT prolongation, and solifenacin has been linked to QT prolongation at supratherapeutic doses. Together they may modestly increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Ciprofloxacin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT-interval prolongation.
What to do
Avoid in patients with long QT, hypokalemia, or hypomagnesemia, and correct electrolytes. Consider ECG monitoring in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Solifenacin?
MediHelp rates the interaction as moderate. Ciprofloxacin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin carries a small risk of QT prolongation, and solifenacin has been linked to QT prolongation at supratherapeutic doses. Together they may modestly increase arrhythmia risk in susceptible patients.
How serious is the interaction between Ciprofloxacin and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with long QT, hypokalemia, or hypomagnesemia, and correct electrolytes. Consider ECG monitoring in high-risk patients.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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