Drug interactions
Cisapride + Danazol
Severity: Contraindicated
Cisapride and Danazol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4 and can increase cisapride concentrations. Elevated cisapride raises risk of QT prolongation and life-threatening ventricular arrhythmias.
What this interaction means in plain words
Cisapride and Danazol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of CYP3A4-mediated cisapride metabolism increases its plasma concentration.
What to do
Avoid concurrent use; choose an alternative prokinetic or alternative to danazol. Do not combine since arrhythmia risk cannot be reliably monitored.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Frequently asked questions
Can I take Cisapride with Danazol?
MediHelp rates the interaction as contraindicated. Cisapride and Danazol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Danazol inhibits CYP3A4 and can increase cisapride concentrations. Elevated cisapride raises risk of QT prolongation and life-threatening ventricular arrhythmias.
How serious is the interaction between Cisapride and Danazol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose an alternative prokinetic or alternative to danazol. Do not combine since arrhythmia risk cannot be reliably monitored.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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