Drug interactions
Cisapride + Hydrocortisone
Severity: Minor
Cisapride and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is a weak CYP3A4 inducer at most, so any reduction in cisapride exposure is small and unlikely to be clinically meaningful. This does not represent a serious interaction, and a decrease in cisapride levels is not a safety concern.
What this interaction means in plain words
Cisapride and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cisapride belongs to Gastrointestinal Tract; Hydrocortisone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 induction, which is not well established for hydrocortisone.
What to do
No specific action is needed beyond awareness; monitor the clinical response to cisapride if long-term high-dose corticosteroids are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Cisapride with Hydrocortisone?
MediHelp rates the interaction as minor. Cisapride and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is a weak CYP3A4 inducer at most, so any reduction in cisapride exposure is small and unlikely to be clinically meaningful. This does not represent a serious interaction, and a decrease in cisapride levels is not a safety concern.
How serious is the interaction between Cisapride and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond awareness; monitor the clinical response to cisapride if long-term high-dose corticosteroids are used.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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