Drug interactions
Cisatracurium + Corticotropin
Severity: Moderate
Cisatracurium and Corticotropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates endogenous corticosteroid release, and corticosteroids given with nondepolarizing neuromuscular blockers, mainly during prolonged ICU use, have been linked to acute myopathy. Patients may show prolonged weakness and delayed recovery of muscle strength or difficulty weaning from ventilation.
What this interaction means in plain words
Cisatracurium and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisatracurium belongs to Musculoskeletal; Corticotropin belongs to Endocrine.
Why it happens
Corticosteroid-induced muscle catabolism combined with prolonged neuromuscular blockade appears to contribute to acute quadriplegic myopathy; the exact mechanism is not fully established.
What to do
Use the lowest effective dose and shortest duration of cisatracurium, monitoring neuromuscular function with train-of-four testing. Assess for new weakness and consider checking creatine kinase if myopathy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisatracurium
Other interactions of Corticotropin
Frequently asked questions
Can I take Cisatracurium with Corticotropin?
MediHelp rates the interaction as moderate. Cisatracurium and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates endogenous corticosteroid release, and corticosteroids given with nondepolarizing neuromuscular blockers, mainly during prolonged ICU use, have been linked to acute myopathy. Patients may show prolonged weakness and delayed recovery of muscle strength or difficulty weaning from ventilation.
How serious is the interaction between Cisatracurium and Corticotropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose and shortest duration of cisatracurium, monitoring neuromuscular function with train-of-four testing. Assess for new weakness and consider checking creatine kinase if myopathy is suspected.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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