Drug interactions
Cisatracurium + Nisoldipine
Severity: Minor
Cisatracurium and Nisoldipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers may enhance and prolong neuromuscular blockade from non-depolarizing agents. The effect with nisoldipine and cisatracurium is probably small but may delay recovery.
What this interaction means in plain words
Cisatracurium and Nisoldipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cisatracurium belongs to Musculoskeletal; Nisoldipine belongs to Cardiovascular.
Why it happens
Calcium channel blockade reduces presynaptic acetylcholine release, adding to cisatracurium blockade.
What to do
Monitor neuromuscular function with train-of-four and dose cisatracurium to effect. Allow for slower recovery before extubation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisatracurium
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Cisatracurium with Nisoldipine?
MediHelp rates the interaction as minor. Cisatracurium and Nisoldipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers may enhance and prolong neuromuscular blockade from non-depolarizing agents. The effect with nisoldipine and cisatracurium is probably small but may delay recovery.
How serious is the interaction between Cisatracurium and Nisoldipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and dose cisatracurium to effect. Allow for slower recovery before extubation.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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