Drug interactions
Cisplatin + Neomycin
Severity: Moderate
Cisplatin and Neomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cisplatin is strongly nephrotoxic and ototoxic, and aminoglycosides share both toxicities. Oral neomycin is poorly absorbed, but absorption can rise with mucosal damage, such as chemotherapy-induced mucositis, or with reduced renal clearance. In that setting the combined risk of hearing loss and kidney injury increases.
What this interaction means in plain words
Cisplatin and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Neomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxic and ototoxic effects on renal tubular cells and cochlear hair cells when neomycin is absorbed systemically.
What to do
Avoid prolonged or high-dose oral neomycin during cisplatin therapy where possible. If both are needed, monitor serum creatinine and electrolytes, and obtain baseline and follow-up audiometry.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Neomycin?
MediHelp rates the interaction as moderate. Cisplatin and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cisplatin is strongly nephrotoxic and ototoxic, and aminoglycosides share both toxicities. Oral neomycin is poorly absorbed, but absorption can rise with mucosal damage, such as chemotherapy-induced mucositis, or with reduced renal clearance. In that setting the combined risk of hearing loss and kidney injury increases.
How serious is the interaction between Cisplatin and Neomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged or high-dose oral neomycin during cisplatin therapy where possible. If both are needed, monitor serum creatinine and electrolytes, and obtain baseline and follow-up audiometry.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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