Drug interactions
Cisplatin + Paclitaxel
Severity: Moderate
Cisplatin and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
When cisplatin is given before paclitaxel, paclitaxel clearance is reduced and myelosuppression is more profound than with the reverse order. Neuropathy is also additive with this combination.
What this interaction means in plain words
Cisplatin and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Cisplatin reduces paclitaxel clearance, and both drugs have overlapping neurotoxic and myelosuppressive effects.
What to do
Give paclitaxel before cisplatin as in standard regimens. Monitor blood counts and peripheral neuropathy and adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Cisplatin with Paclitaxel?
MediHelp rates the interaction as moderate. Cisplatin and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. When cisplatin is given before paclitaxel, paclitaxel clearance is reduced and myelosuppression is more profound than with the reverse order. Neuropathy is also additive with this combination.
How serious is the interaction between Cisplatin and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give paclitaxel before cisplatin as in standard regimens. Monitor blood counts and peripheral neuropathy and adjust doses as needed.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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