Drug interactions
Citalopram + Lisdexamfetamine
Severity: Moderate
Citalopram and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisdexamfetamine releases monoamines including serotonin and, together with an SSRI, can raise the risk of serotonin syndrome. Features include agitation, tremor, hyperthermia, sweating, diarrhea and neuromuscular hyperactivity. The risk is greatest at initiation or after dose increases.
What this interaction means in plain words
Citalopram and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity through amphetamine-induced serotonin release combined with SSRI-mediated reuptake inhibition.
What to do
Start lisdexamfetamine at a low dose and titrate slowly while watching for signs of serotonin syndrome. Stop both serotonergic agents and give supportive care if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Citalopram with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Citalopram and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisdexamfetamine releases monoamines including serotonin and, together with an SSRI, can raise the risk of serotonin syndrome. Features include agitation, tremor, hyperthermia, sweating, diarrhea and neuromuscular hyperactivity. The risk is greatest at initiation or after dose increases.
How serious is the interaction between Citalopram and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start lisdexamfetamine at a low dose and titrate slowly while watching for signs of serotonin syndrome. Stop both serotonergic agents and give supportive care if it develops.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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