Drug interactions
Citalopram + Ticlopidine
Severity: Major
Citalopram and Ticlopidine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2C19, which raises citalopram concentrations and may increase QT prolongation risk. SSRIs also add to antiplatelet-related bleeding risk.
What this interaction means in plain words
Citalopram and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Ticlopidine belongs to Cardiovascular.
Why it happens
CYP2C19 inhibition by ticlopidine reduces citalopram clearance; additive platelet effects of SSRI and antiplatelet.
What to do
Limit citalopram to 20 mg daily and consider ECG monitoring. Monitor for bleeding or choose an alternative antidepressant or antiplatelet.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ticlopidine
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Ticlopidine?
MediHelp rates the interaction as major. Citalopram and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticlopidine inhibits CYP2C19, which raises citalopram concentrations and may increase QT prolongation risk. SSRIs also add to antiplatelet-related bleeding risk.
How serious is the interaction between Citalopram and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit citalopram to 20 mg daily and consider ECG monitoring. Monitor for bleeding or choose an alternative antidepressant or antiplatelet.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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