Drug interactions
Citalopram + Toremifene
Severity: Major
Citalopram and Toremifene: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong the QT interval in a dose-dependent manner. Using them together raises the risk of torsades de pointes and toremifene labeling advises against combining it with QT-prolonging drugs.
What this interaction means in plain words
Citalopram and Toremifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Toremifene belongs to Endocrine.
Why it happens
Additive QT prolongation via blockade of cardiac repolarizing potassium currents.
What to do
Avoid the combination where possible, for example by using a non-QT-prolonging antidepressant such as sertraline. If unavoidable, monitor ECG and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Citalopram with Toremifene?
MediHelp rates the interaction as major. Citalopram and Toremifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents prolong the QT interval in a dose-dependent manner. Using them together raises the risk of torsades de pointes and toremifene labeling advises against combining it with QT-prolonging drugs.
How serious is the interaction between Citalopram and Toremifene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, for example by using a non-QT-prolonging antidepressant such as sertraline. If unavoidable, monitor ECG and keep potassium and magnesium normal.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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