Drug interactions
Citalopram + Tucatinib
Severity: Moderate
Citalopram and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a moderate CYP3A inhibitor that may increase citalopram exposure. Higher citalopram levels increase the risk of dose-related QT prolongation and serotonergic adverse effects.
What this interaction means in plain words
Citalopram and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by tucatinib reduces citalopram clearance.
What to do
Monitor for increased citalopram adverse effects and consider an ECG in patients with QT risk factors. Reduce the citalopram dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Citalopram with Tucatinib?
MediHelp rates the interaction as moderate. Citalopram and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a moderate CYP3A inhibitor that may increase citalopram exposure. Higher citalopram levels increase the risk of dose-related QT prolongation and serotonergic adverse effects.
How serious is the interaction between Citalopram and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased citalopram adverse effects and consider an ECG in patients with QT risk factors. Reduce the citalopram dose if adverse effects emerge.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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