Drug interactions
Clarithromycin + Darolutamide
Severity: Moderate
Clarithromycin and Darolutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may raise darolutamide exposure, increasing risk of adverse effects such as fatigue and, rarely, cardiac events. The effect is expected from combined P-gp and CYP3A4 inhibition.
What this interaction means in plain words
Clarithromycin and Darolutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Darolutamide belongs to Miscellaneous.
Why it happens
Inhibition of P-gp and CYP3A4 reduces darolutamide efflux and metabolism.
What to do
Monitor for darolutamide toxicity and reduce the dose if adverse reactions occur; consider a non-interacting antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Darolutamide
Frequently asked questions
Can I take Clarithromycin with Darolutamide?
MediHelp rates the interaction as moderate. Clarithromycin and Darolutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may raise darolutamide exposure, increasing risk of adverse effects such as fatigue and, rarely, cardiac events. The effect is expected from combined P-gp and CYP3A4 inhibition.
How serious is the interaction between Clarithromycin and Darolutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for darolutamide toxicity and reduce the dose if adverse reactions occur; consider a non-interacting antibiotic.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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