Drug interactions
Clarithromycin + Histrelin
Severity: Moderate
Clarithromycin and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, can prolong the QT interval by lowering androgen levels, and clarithromycin is a macrolide that also prolongs QT. Used together, the risk of QT prolongation and torsades de pointes may be higher.
What this interaction means in plain words
Clarithromycin and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Histrelin belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic QT prolongation from androgen deprivation (histrelin) and macrolide-related cardiac repolarization effects (clarithromycin).
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before combining. Consider an alternative antibiotic such as doxycycline, or monitor ECG, in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Clarithromycin with Histrelin?
MediHelp rates the interaction as moderate. Clarithromycin and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, can prolong the QT interval by lowering androgen levels, and clarithromycin is a macrolide that also prolongs QT. Used together, the risk of QT prolongation and torsades de pointes may be higher.
How serious is the interaction between Clarithromycin and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before combining. Consider an alternative antibiotic such as doxycycline, or monitor ECG, in patients with other QT risk factors.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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