Drug interactions
Clarithromycin + Lenacapavir
Severity: Moderate
Clarithromycin and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor with a very long residence time after subcutaneous dosing. It may raise clarithromycin concentrations, increasing its adverse effects, including QT prolongation.
What this interaction means in plain words
Clarithromycin and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, reducing clarithromycin metabolism.
What to do
Monitor for clarithromycin adverse effects such as GI intolerance and QT prolongation. Consider an alternative antibiotic when renal impairment or other risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Clarithromycin with Lenacapavir?
MediHelp rates the interaction as moderate. Clarithromycin and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor with a very long residence time after subcutaneous dosing. It may raise clarithromycin concentrations, increasing its adverse effects, including QT prolongation.
How serious is the interaction between Clarithromycin and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clarithromycin adverse effects such as GI intolerance and QT prolongation. Consider an alternative antibiotic when renal impairment or other risk factors are present.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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