Drug interactions
Clarithromycin + Naldemedine
Severity: Moderate
Clarithromycin and Naldemedine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is a CYP3A4 and P-gp substrate, and clarithromycin inhibits both pathways, increasing naldemedine exposure. This may increase gastrointestinal effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Clarithromycin and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP3A4 metabolism and P-gp efflux of naldemedine by clarithromycin.
What to do
Monitor for abdominal pain, diarrhea and opioid withdrawal symptoms. Stop or reduce naldemedine if GI effects become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clarithromycin and Naldemedine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Clarithromycin with Naldemedine?
MediHelp rates the interaction as moderate. Clarithromycin and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naldemedine is a CYP3A4 and P-gp substrate, and clarithromycin inhibits both pathways, increasing naldemedine exposure. This may increase gastrointestinal effects such as abdominal pain and diarrhea.
How serious is the interaction between Clarithromycin and Naldemedine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal pain, diarrhea and opioid withdrawal symptoms. Stop or reduce naldemedine if GI effects become troublesome.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
