Drug interactions
Clemastine + Metoclopramide
Severity: Moderate
Clemastine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating antihistamine and metoclopramide can also cause drowsiness. Together they may increase sedation and impair alertness.
What this interaction means in plain words
Clemastine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depressant effects.
What to do
Advise the patient about drowsiness and driving. Use a non-sedating antihistamine if sedation becomes problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Metoclopramide?
MediHelp rates the interaction as moderate. Clemastine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating antihistamine and metoclopramide can also cause drowsiness. Together they may increase sedation and impair alertness.
How serious is the interaction between Clemastine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient about drowsiness and driving. Use a non-sedating antihistamine if sedation becomes problematic.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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