Drug interactions
Clemastine + Prochlorperazine
Severity: Moderate
Clemastine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating and clemastine has marked anticholinergic activity. Combined use can cause excess drowsiness, dry mouth, urinary retention and confusion, especially in older patients.
What this interaction means in plain words
Clemastine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive antihistaminic, anticholinergic and CNS depressant effects.
What to do
Monitor for oversedation and anticholinergic toxicity and reduce doses if needed. Warn patients against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Prochlorperazine?
MediHelp rates the interaction as moderate. Clemastine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating and clemastine has marked anticholinergic activity. Combined use can cause excess drowsiness, dry mouth, urinary retention and confusion, especially in older patients.
How serious is the interaction between Clemastine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity and reduce doses if needed. Warn patients against driving.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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