Drug interactions
Clemastine + Propofol
Severity: Moderate
Clemastine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating antihistamine that can increase the sedative effect of propofol and delay recovery.
What this interaction means in plain words
Clemastine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression through H1 antagonism and GABAergic activity.
What to do
Use lower propofol doses titrated to effect and monitor sedation and respiration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Propofol?
MediHelp rates the interaction as moderate. Clemastine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating antihistamine that can increase the sedative effect of propofol and delay recovery.
How serious is the interaction between Clemastine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower propofol doses titrated to effect and monitor sedation and respiration.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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