Drug interactions
Clevidipine + Nadolol
Severity: Moderate
Clevidipine and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and combining them may produce excessive hypotension or bradycardia-related effects. Beta-blockers can also blunt the reflex tachycardia that normally accompanies dihydropyridine vasodilation.
What this interaction means in plain words
Clevidipine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects from beta-blockade and calcium channel blockade.
What to do
Titrate clevidipine to blood pressure with continuous monitoring in patients taking nadolol, and reduce the infusion rate if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clevidipine and Nadolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nadolol
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Nadolol?
MediHelp rates the interaction as moderate. Clevidipine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and combining them may produce excessive hypotension or bradycardia-related effects. Beta-blockers can also blunt the reflex tachycardia that normally accompanies dihydropyridine vasodilation.
How serious is the interaction between Clevidipine and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine to blood pressure with continuous monitoring in patients taking nadolol, and reduce the infusion rate if hypotension develops.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
