Drug interactions
Clevidipine + Nebivolol
Severity: Moderate
Clevidipine and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so giving them together can produce additive hypotension. Beta-blockade may also blunt the reflex tachycardia that normally accompanies dihydropyridine vasodilation.
What this interaction means in plain words
Clevidipine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering from beta-blockade and arteriolar calcium channel blockade.
What to do
Titrate clevidipine infusion against blood pressure and heart rate with frequent monitoring. Reduce the dose of either agent if hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Nebivolol?
MediHelp rates the interaction as moderate. Clevidipine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so giving them together can produce additive hypotension. Beta-blockade may also blunt the reflex tachycardia that normally accompanies dihydropyridine vasodilation.
How serious is the interaction between Clevidipine and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine infusion against blood pressure and heart rate with frequent monitoring. Reduce the dose of either agent if hypotension or bradycardia develops.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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