Drug interactions
Clevidipine + Phentolamine
Severity: Moderate
Clevidipine and Phentolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure through vasodilation by different mechanisms. Together they may produce excessive hypotension and reflex tachycardia.
What this interaction means in plain words
Clevidipine and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Phentolamine belongs to Cardiovascular.
Why it happens
Additive vasodilation from alpha-adrenergic blockade and L-type calcium channel blockade.
What to do
Titrate clevidipine carefully with continuous blood pressure and heart rate monitoring. Reduce the dose of either agent if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phentolamine
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Phentolamine?
MediHelp rates the interaction as moderate. Clevidipine and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure through vasodilation by different mechanisms. Together they may produce excessive hypotension and reflex tachycardia.
How serious is the interaction between Clevidipine and Phentolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine carefully with continuous blood pressure and heart rate monitoring. Reduce the dose of either agent if hypotension occurs.
What other medicines interact with Phentolamine?
MediHelp also lists interactions of Phentolamine with, for example, Alfuzosin, Avanafil, Doxazosin. The full list is on the Phentolamine page.
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