Drug interactions
Clindamycin + Digoxin
Severity: Minor
Clindamycin and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Evidence for an interaction is weak. Digoxin is partly inactivated by gut bacteria such as Eubacterium lentum, and antibiotics that suppress them can raise digoxin levels, but this is chiefly described with macrolides and tetracyclines rather than clindamycin.
What this interaction means in plain words
Clindamycin and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clindamycin belongs to Anti Bacterial; Digoxin belongs to Cardiovascular.
Why it happens
Possible reduced bacterial inactivation of digoxin in the gut, increasing absorption.
What to do
Check digoxin concentration and watch for toxicity symptoms if the patient has a narrow margin or is on a prolonged oral clindamycin course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clindamycin
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Clindamycin with Digoxin?
MediHelp rates the interaction as minor. Clindamycin and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Evidence for an interaction is weak. Digoxin is partly inactivated by gut bacteria such as Eubacterium lentum, and antibiotics that suppress them can raise digoxin levels, but this is chiefly described with macrolides and tetracyclines rather than clindamycin.
How serious is the interaction between Clindamycin and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check digoxin concentration and watch for toxicity symptoms if the patient has a narrow margin or is on a prolonged oral clindamycin course.
What other medicines interact with Clindamycin?
MediHelp also lists interactions of Clindamycin with, for example, Atracurium, Cisatracurium, Microbiota. The full list is on the Clindamycin page.
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