Drug interactions
Clobazam + Dextromethorphan
Severity: Moderate
Clobazam and Dextromethorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam, mainly via its metabolite, is a weak to moderate CYP2D6 inhibitor and may increase dextromethorphan concentrations. This can enhance dextromethorphan adverse effects, and both drugs can cause drowsiness and dizziness.
What this interaction means in plain words
Clobazam and Dextromethorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Dextromethorphan belongs to Respiratory.
Why it happens
Inhibition of CYP2D6 metabolism of dextromethorphan by clobazam, plus additive CNS effects.
What to do
Monitor for sedation, dizziness and confusion, and use the lowest effective dextromethorphan dose. Counsel patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Dextromethorphan?
MediHelp rates the interaction as moderate. Clobazam and Dextromethorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam, mainly via its metabolite, is a weak to moderate CYP2D6 inhibitor and may increase dextromethorphan concentrations. This can enhance dextromethorphan adverse effects, and both drugs can cause drowsiness and dizziness.
How serious is the interaction between Clobazam and Dextromethorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and confusion, and use the lowest effective dextromethorphan dose. Counsel patients to avoid driving until the response is known.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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