Drug interactions
Clobazam + Dutasteride-tamsulosin
Severity: Minor
Clobazam and Dutasteride-tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam, through its metabolite, is a weak CYP2D6 inhibitor and may modestly increase tamsulosin exposure. This may increase dizziness or orthostatic hypotension, and clobazam sedation may add to these effects.
What this interaction means in plain words
Clobazam and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clobazam belongs to Central Nervous System; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Weak inhibition of CYP2D6-mediated tamsulosin metabolism.
What to do
Counsel patients about dizziness and rising slowly. Monitor blood pressure if symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Dutasteride-tamsulosin?
MediHelp rates the interaction as minor. Clobazam and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clobazam, through its metabolite, is a weak CYP2D6 inhibitor and may modestly increase tamsulosin exposure. This may increase dizziness or orthostatic hypotension, and clobazam sedation may add to these effects.
How serious is the interaction between Clobazam and Dutasteride-tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about dizziness and rising slowly. Monitor blood pressure if symptoms develop.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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