Drug interactions
Clobazam + Flecainide
Severity: Moderate
Clobazam and Flecainide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam, particularly its metabolite, is a weak CYP2D6 inhibitor and may raise flecainide exposure. Higher flecainide levels increase the risk of conduction slowing and proarrhythmia.
What this interaction means in plain words
Clobazam and Flecainide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Flecainide belongs to Cardiovascular.
Why it happens
Clobazam inhibits CYP2D6, reducing flecainide metabolism.
What to do
Monitor ECG (PR and QRS duration) and flecainide levels if available when clobazam is started. Reduce the flecainide dose if conduction intervals lengthen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Flecainide?
MediHelp rates the interaction as moderate. Clobazam and Flecainide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam, particularly its metabolite, is a weak CYP2D6 inhibitor and may raise flecainide exposure. Higher flecainide levels increase the risk of conduction slowing and proarrhythmia.
How serious is the interaction between Clobazam and Flecainide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG (PR and QRS duration) and flecainide levels if available when clobazam is started. Reduce the flecainide dose if conduction intervals lengthen.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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