Drug interactions
Clobazam + Fluoxetine
Severity: Moderate
Clobazam and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine inhibits CYP2C19, which converts clobazam's active metabolite N-desmethylclobazam to inactive products, so levels of the active metabolite can increase. This can raise sedation and psychomotor impairment, and the two drugs also add CNS depression.
What this interaction means in plain words
Clobazam and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Fluoxetine belongs to Central Nervous System.
Why it happens
Fluoxetine and norfluoxetine inhibit CYP2C19 (and CYP3A4 weakly), reducing clearance of N-desmethylclobazam.
What to do
Monitor for sedation, ataxia and loss of coordination and reduce the clobazam dose if these occur. Consider dose adjustment when starting or stopping fluoxetine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Fluoxetine?
MediHelp rates the interaction as moderate. Clobazam and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine inhibits CYP2C19, which converts clobazam's active metabolite N-desmethylclobazam to inactive products, so levels of the active metabolite can increase. This can raise sedation and psychomotor impairment, and the two drugs also add CNS depression.
How serious is the interaction between Clobazam and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, ataxia and loss of coordination and reduce the clobazam dose if these occur. Consider dose adjustment when starting or stopping fluoxetine.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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