Drug interactions
Clobazam + Maprotiline
Severity: Moderate
Clobazam and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam and its active metabolite are weak CYP2D6 inhibitors and may raise maprotiline concentrations. The combination also adds CNS and respiratory depression, with more sedation and psychomotor impairment. Maprotiline lowers the seizure threshold, which may work against clobazam in patients with epilepsy.
What this interaction means in plain words
Clobazam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition by clobazam metabolite plus additive CNS depression.
What to do
Monitor for sedation, respiratory depression and signs of maprotiline excess, and reduce the maprotiline dose if adverse effects appear. Watch seizure control in patients with epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Maprotiline?
MediHelp rates the interaction as moderate. Clobazam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam and its active metabolite are weak CYP2D6 inhibitors and may raise maprotiline concentrations. The combination also adds CNS and respiratory depression, with more sedation and psychomotor impairment. Maprotiline lowers the seizure threshold, which may work against clobazam in patients with epilepsy.
How serious is the interaction between Clobazam and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and signs of maprotiline excess, and reduce the maprotiline dose if adverse effects appear. Watch seizure control in patients with epilepsy.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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