Drug interactions
Clobazam + Mexiletine
Severity: Minor
Clobazam and Mexiletine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam and its metabolite are weak CYP2D6 inhibitors, so mexiletine levels may rise slightly. Mexiletine toxicity, including tremor, dizziness and arrhythmia, is possible if exposure increases markedly. Additive CNS effects may also occur.
What this interaction means in plain words
Clobazam and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clobazam belongs to Central Nervous System; Mexiletine belongs to Cardiovascular.
Why it happens
Weak CYP2D6 inhibition by clobazam may reduce mexiletine metabolism.
What to do
Monitor for mexiletine adverse effects such as dizziness, tremor and GI upset when starting clobazam, and reduce the mexiletine dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Mexiletine?
MediHelp rates the interaction as minor. Clobazam and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clobazam and its metabolite are weak CYP2D6 inhibitors, so mexiletine levels may rise slightly. Mexiletine toxicity, including tremor, dizziness and arrhythmia, is possible if exposure increases markedly. Additive CNS effects may also occur.
How serious is the interaction between Clobazam and Mexiletine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mexiletine adverse effects such as dizziness, tremor and GI upset when starting clobazam, and reduce the mexiletine dose if they appear.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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