Drug interactions
Clobazam + Nicardipine
Severity: Minor
Clobazam and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may inhibit CYP2C19 and increase levels of the active metabolite N-desmethylclobazam, with possible sedation and drowsiness. The effect is probably modest.
What this interaction means in plain words
Clobazam and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clobazam belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C19-mediated clobazam metabolism by nicardipine.
What to do
Monitor for increased sedation, ataxia and dizziness. Reduce the clobazam dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Nicardipine?
MediHelp rates the interaction as minor. Clobazam and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine may inhibit CYP2C19 and increase levels of the active metabolite N-desmethylclobazam, with possible sedation and drowsiness. The effect is probably modest.
How serious is the interaction between Clobazam and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation, ataxia and dizziness. Reduce the clobazam dose if adverse effects occur.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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