Drug interactions
Clobazam + Pramipexole
Severity: Moderate
Clobazam and Pramipexole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a sedating benzodiazepine and pramipexole commonly causes somnolence, so the combination may intensify drowsiness and psychomotor impairment. Falls and sudden sleep episodes are a particular concern in older patients.
What this interaction means in plain words
Clobazam and Pramipexole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Pramipexole belongs to Cardiovascular.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and falls and use the lowest effective doses; advise patients to avoid driving if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Pramipexole?
MediHelp rates the interaction as moderate. Clobazam and Pramipexole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a sedating benzodiazepine and pramipexole commonly causes somnolence, so the combination may intensify drowsiness and psychomotor impairment. Falls and sudden sleep episodes are a particular concern in older patients.
How serious is the interaction between Clobazam and Pramipexole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and falls and use the lowest effective doses; advise patients to avoid driving if drowsy.
What other medicines interact with Pramipexole?
MediHelp also lists interactions of Pramipexole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Pramipexole page.
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