Drug interactions
Clobazam + Propafenone
Severity: Minor
Clobazam and Propafenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam, or its active metabolite, is a weak CYP2D6 inhibitor and may raise propafenone concentrations modestly. Higher propafenone exposure can increase conduction slowing, bradycardia and proarrhythmic risk.
What this interaction means in plain words
Clobazam and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clobazam belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP2D6-mediated propafenone metabolism by clobazam.
What to do
Monitor heart rate and ECG (PR and QRS intervals) when clobazam is started or stopped. Reduce the propafenone dose if conduction abnormalities or adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Propafenone?
MediHelp rates the interaction as minor. Clobazam and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clobazam, or its active metabolite, is a weak CYP2D6 inhibitor and may raise propafenone concentrations modestly. Higher propafenone exposure can increase conduction slowing, bradycardia and proarrhythmic risk.
How serious is the interaction between Clobazam and Propafenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG (PR and QRS intervals) when clobazam is started or stopped. Reduce the propafenone dose if conduction abnormalities or adverse effects appear.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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