Drug interactions
Clofarabine + Trastuzumab
Severity: Moderate
Clofarabine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clofarabine causes profound myelosuppression, and trastuzumab with myelosuppressive therapy has been associated with more neutropenia and febrile neutropenia. Infection risk may be higher with both.
What this interaction means in plain words
Clofarabine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clofarabine belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression, mainly from clofarabine's inhibition of DNA synthesis in hematopoietic cells.
What to do
Monitor blood counts frequently and assess for infection. Adjust clofarabine dose or give supportive care for severe neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Clofarabine
- Clofarabine + Siponimod Major
- Clofarabine + Tofacitinib Major
- Amlodipine-benazepril + Clofarabine Moderate
- Benazepril + Clofarabine Moderate
- Captopril-hydrochlorothiazide + Clofarabine Moderate
- Captopril + Clofarabine Moderate
Frequently asked questions
Can I take Clofarabine with Trastuzumab?
MediHelp rates the interaction as moderate. Clofarabine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clofarabine causes profound myelosuppression, and trastuzumab with myelosuppressive therapy has been associated with more neutropenia and febrile neutropenia. Infection risk may be higher with both.
How serious is the interaction between Clofarabine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts frequently and assess for infection. Adjust clofarabine dose or give supportive care for severe neutropenia.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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