Drug interactions
Clofazimine + Fostemsavir
Severity: Moderate
Clofazimine and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clofazimine prolongs the QT interval and fostemsavir has caused QT prolongation at supratherapeutic doses. Combined use may add to arrhythmia risk, though fostemsavir at standard doses has limited effect.
What this interaction means in plain words
Clofazimine and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clofazimine belongs to Anti Bacterial; Fostemsavir belongs to Anti Virals.
Why it happens
Additive QT prolongation effects.
What to do
Obtain a baseline ECG and monitor QTc periodically, particularly with other risk factors. Correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clofazimine
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Clofazimine with Fostemsavir?
MediHelp rates the interaction as moderate. Clofazimine and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clofazimine prolongs the QT interval and fostemsavir has caused QT prolongation at supratherapeutic doses. Combined use may add to arrhythmia risk, though fostemsavir at standard doses has limited effect.
How serious is the interaction between Clofazimine and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc periodically, particularly with other risk factors. Correct electrolyte abnormalities.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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