Drug interactions
Clofazimine + Voclosporin
Severity: Moderate
Clofazimine and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can prolong the QT interval at higher exposures, and clofazimine may also do so. Together they may increase the risk of arrhythmias, especially with electrolyte abnormalities.
What this interaction means in plain words
Clofazimine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clofazimine belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Check ECG and electrolytes at baseline and during co-treatment, and correct potassium and magnesium deficits. Reassess the combination if QTc lengthens meaningfully.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clofazimine
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Clofazimine with Voclosporin?
MediHelp rates the interaction as moderate. Clofazimine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can prolong the QT interval at higher exposures, and clofazimine may also do so. Together they may increase the risk of arrhythmias, especially with electrolyte abnormalities.
How serious is the interaction between Clofazimine and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and during co-treatment, and correct potassium and magnesium deficits. Reassess the combination if QTc lengthens meaningfully.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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