Drug interactions
Clomipramine + Deutetrabenazine
Severity: Moderate
Clomipramine and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, and each may prolong the QT interval, so combined use may increase the risk of arrhythmia, particularly with other risk factors. Deutetrabenazine can also cause depression, which complicates treatment in patients taking antidepressants.
What this interaction means in plain words
Clomipramine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and QT prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium abnormalities. Monitor for sedation and QT changes, and avoid additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Clomipramine with Deutetrabenazine?
MediHelp rates the interaction as moderate. Clomipramine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, and each may prolong the QT interval, so combined use may increase the risk of arrhythmia, particularly with other risk factors. Deutetrabenazine can also cause depression, which complicates treatment in patients taking antidepressants.
How serious is the interaction between Clomipramine and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium abnormalities. Monitor for sedation and QT changes, and avoid additional QT-prolonging drugs.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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