Drug interactions
Clomipramine + Diclofenac
Severity: Moderate
Clomipramine and Diclofenac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine blocks serotonin reuptake into platelets, which impairs platelet aggregation, and diclofenac adds gastric mucosal injury and antiplatelet effects. Together they raise the risk of gastrointestinal bleeding above that of either drug alone.
What this interaction means in plain words
Clomipramine and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Diclofenac belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect: serotonin reuptake inhibition reduces platelet function while NSAID-induced COX inhibition damages gastric mucosa and inhibits platelets.
What to do
Use the lowest effective diclofenac dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Advise patients to report black stools or hematemesis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Diclofenac?
MediHelp rates the interaction as moderate. Clomipramine and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine blocks serotonin reuptake into platelets, which impairs platelet aggregation, and diclofenac adds gastric mucosal injury and antiplatelet effects. Together they raise the risk of gastrointestinal bleeding above that of either drug alone.
How serious is the interaction between Clomipramine and Diclofenac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Advise patients to report black stools or hematemesis.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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