Drug interactions
Clomipramine + Dutasteride-tamsulosin
Severity: Moderate
Clomipramine and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine inhibits CYP2D6 to a moderate degree and also has alpha-1 blocking effects. Combined with tamsulosin it may raise tamsulosin levels and add to orthostatic hypotension.
What this interaction means in plain words
Clomipramine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
CYP2D6 inhibition by clomipramine plus additive alpha-adrenergic blockade.
What to do
Monitor for orthostatic hypotension and dizziness, especially in older patients. Reduce tamsulosin dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Clomipramine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine inhibits CYP2D6 to a moderate degree and also has alpha-1 blocking effects. Combined with tamsulosin it may raise tamsulosin levels and add to orthostatic hypotension.
How serious is the interaction between Clomipramine and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and dizziness, especially in older patients. Reduce tamsulosin dose if symptomatic.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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