Drug interactions
Clomipramine + Etodolac
Severity: Moderate
Clomipramine and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine, a potent serotonin reuptake inhibitor, can add to the bleeding tendency of etodolac and increase the risk of upper gastrointestinal bleeding.
What this interaction means in plain words
Clomipramine and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Etodolac belongs to Musculoskeletal.
Why it happens
Inhibition of platelet serotonin uptake impairs aggregation, adding to NSAID platelet inhibition and mucosal injury.
What to do
Consider a proton pump inhibitor for gastroprotection and counsel patients to report black stools or hematemesis. Use an alternative analgesic if risk factors for bleeding are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Etodolac?
MediHelp rates the interaction as moderate. Clomipramine and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine, a potent serotonin reuptake inhibitor, can add to the bleeding tendency of etodolac and increase the risk of upper gastrointestinal bleeding.
How serious is the interaction between Clomipramine and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor for gastroprotection and counsel patients to report black stools or hematemesis. Use an alternative analgesic if risk factors for bleeding are present.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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