Drug interactions
Clomipramine + Fluticasone-vilanterol
Severity: Major
Clomipramine and Fluticasone-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine can potentiate the cardiovascular effects of vilanterol, producing tachycardia, arrhythmias and blood pressure changes, and it also prolongs the QT interval. The vilanterol label advises extreme caution with tricyclic antidepressants.
What this interaction means in plain words
Clomipramine and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Tricyclic noradrenaline reuptake inhibition and QT prolongation add to beta-2 agonist cardiac stimulation.
What to do
Monitor heart rate, blood pressure and ECG, especially at initiation and in cardiac disease. Correct electrolytes and reconsider therapy if arrhythmia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clomipramine and Fluticasone-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluticasone-vilanterol
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Clomipramine and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clomipramine can potentiate the cardiovascular effects of vilanterol, producing tachycardia, arrhythmias and blood pressure changes, and it also prolongs the QT interval. The vilanterol label advises extreme caution with tricyclic antidepressants.
How serious is the interaction between Clomipramine and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, especially at initiation and in cardiac disease. Correct electrolytes and reconsider therapy if arrhythmia develops.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
