Drug interactions
Clomipramine + Gabapentin enacarbil
Severity: Moderate
Clomipramine and Gabapentin enacarbil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, and gabapentinoids with other CNS depressants can cause marked sedation and respiratory depression, particularly in older patients or those with lung disease. Clomipramine adds sedative and anticholinergic effects.
What this interaction means in plain words
Clomipramine and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, especially at initiation and dose increases. Take extra care in patients with respiratory compromise or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Clomipramine with Gabapentin enacarbil?
MediHelp rates the interaction as moderate. Clomipramine and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, and gabapentinoids with other CNS depressants can cause marked sedation and respiratory depression, particularly in older patients or those with lung disease. Clomipramine adds sedative and anticholinergic effects.
How serious is the interaction between Clomipramine and Gabapentin enacarbil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, especially at initiation and dose increases. Take extra care in patients with respiratory compromise or renal impairment.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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