Drug interactions
Clomipramine + Glycopyrronium
Severity: Moderate
Clomipramine and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a strongly anticholinergic tricyclic antidepressant. With glycopyrronium, additive effects such as dry mouth, constipation, urinary retention, tachycardia, blurred vision and delirium are more likely.
What this interaction means in plain words
Clomipramine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Glycopyrronium belongs to Respiratory.
Why it happens
Additive pharmacodynamic antimuscarinic activity.
What to do
Monitor for anticholinergic effects, particularly in older patients or those with glaucoma, prostatic hypertrophy or ileus; lower the dose or choose a less anticholinergic option if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clomipramine and Glycopyrronium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Glycopyrronium?
MediHelp rates the interaction as moderate. Clomipramine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a strongly anticholinergic tricyclic antidepressant. With glycopyrronium, additive effects such as dry mouth, constipation, urinary retention, tachycardia, blurred vision and delirium are more likely.
How serious is the interaction between Clomipramine and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, particularly in older patients or those with glaucoma, prostatic hypertrophy or ileus; lower the dose or choose a less anticholinergic option if symptomatic.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Potassium chloride, Abobotulinumtoxina. The full list is on the Glycopyrronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
